| Property | Value |
|---|
| Working Groups |  AG El-Armouche,  AG Zimmermann |
| Subproject | A02, C04 |
| Open Access | No |
| Publication Type | Journal Article |
| Peer Reviewed | Unknown |
| PMID |  23771692 |
| DOI |  10.1152/ajpheart.00218.2013 |
| Publication Year | 2013 |
| Title | Preservation of left ventricular function and morphology in volume-loaded versus volume-unloaded heterotopic heart transplants  |
| Journal | American Journal of Physiology-Heart and Circulatory Physiology |
| ISSN | 0363-6135 |
| eISSN | 1522-1539 |
| URL | http://ajpheart.physiology.org/content/305/4/H533 |
| Pages | H533-H541 |
| Issue | 4 |
| Volume | 305 |
| Journal Abbreviation | Am J Physiol-Heart Circul Physiol |
| Extra | Total mechanical unloading of the heart in classical models of heterotopic heart transplantation leads to cardiac atrophy and functional deterioration. In contrast, partial unloading of failing human hearts with left ventricular (LV) assist devices (LVADs) can in some patients ameliorate heart failure symptoms. Here we tested in heterotopic rat heart transplant models whether partial volume-loading (VL; anastomoses: aorta of donor to aorta of recipient, pulmonary artery of donor to left atrium of donor, superior vena cava of donor to inferior vena cava of recipient; n = 27) is superior to the classical model of myocardial unloading (UL; anastomoses: aorta of donor to aorta of recipient, pulmonary artery of donor to inferior vena cava of recipient; n = 14) with respect to preservation of ventricular morphology and function. Echocardiography, magnetic resonance imaging, and LV-pressure-volume catheter revealed attenuated myocardial atrophy with ∼30% higher LV weight and better systolic contractile function in VL compared with UL (fractional area shortening, 34% vs. 18%; maximal change in pressure over time, 2,986 ± 252 vs. 2,032 ± 193 mmHg/s). Interestingly, no differences in fibrosis (Picrosirus red staining) or glucose metabolism (2-[18F]-fluoro-2-deoxy-D-glucose-PET) between VL and UL were observed. We conclude that the rat model of partial VL attenuates atrophic remodelling and shows superior morphological as well as functional preservation, and thus should be considered more widely as a research model. PMID: 23771692 |
| Authors | Didie M, Biermann D, Buchert R, Hess A, Wittköpper K, Christalla P, Döker S, Jebran F, Schöndube F, Reichenspurner H., El-Armouche A., Zimmermann WH |
| First Author | Didie M |
| Last Author | Zimmermann WH |
| Scholia |  Wikidata-based representation at Scholia |
External Resources
journals...8.2013https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00218.2013
Article fulltext
gro-2/6875http://resolver.sub.uni-goettingen.de/purl?gro-2/6875
GRO.publications identifier
10116https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10116
NCBI Taxonomy (Rattus norvegicus)
0000-0003-1190-4040https://orcid.org/0000-0003-1190-4040
ORCID identifier (Wolfram-Hubertus Zimmermann)
031t5w623https://ror.org/031t5w623
ROR identifier (031t5w623, German Centre for Cardiovascular Research)
021ft0n22https://ror.org/021ft0n22
ROR identifier (021ft0n22, University Medical Center Göttingen)
SCR_003070https://scicrunch.org/resolver/SCR_003070
SciCrunch identifier (RRID:SCR_003070, ImageJ)
Q44729878https://www.wikidata.org/wiki/Q44729878
Wikidata ID
