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Publication
PropertyValue
Working Groups AG Cyganek, AG Hasenfuß, AG Linke, AG Tiburcy, AG Zimmermann
SubprojectA08, C04, D01, S01
Open AccessNo
Publication TypeJournal Article
Peer ReviewedYes
PMIDPubMed ID 34731013
DOIDOI 10.1126/scitranslmed.abd3079
Publication Year2021
TitleTruncated titin proteins and titin haploinsufficiency are targets for functional recovery in human cardiomyopathy due to TTN mutations
JournalScience Translational Medicine
ISSN1946-6234
eISSN1946-6242
URL http://dx.doi.org/10.1126/scitranslmed.abd3079
Issue618
Volume13
Journal AbbreviationSci Transl Med
AuthorsFomin A, Gärtner A, Cyganek L, Tiburcy M, Tuleta I, Wellers L, Folsche L, Hobbach AJ, von Frieling-Salewsky M, Unger A, Hucke A, Koser F, Kassner A, Sielemann K, Streckfuß-Bömeke K, Hasenfuss G, Goedel A, Laugwitz K, Moretti A, Gummert JF, dos Remedios CG, Reinecke H, Knöll R, van Heesch S, Hubner N, Zimmermann WH, Milting H, Linke WA
First AuthorFomin A
Last AuthorLinke WA

 External Resources

 science....bd3079  Article fulltext

 gro-2/94394  GRO.publications identifier

 9606  NCBI taxonomy (Homo sapiens, human)

 0000-0001-5578-6977  ORCID identifier (Andrey Fomin)

 0000-0001-6899-7693  ORCID identifier (Anna Gärtner)

 0000-0001-9120-1382  ORCID identifier (Lukas Cyganek)

 0000-0002-6942-6275  ORCID identifier (Malte Tiburcy)

 0000-0003-3752-170X  ORCID identifier (Lina Folsche)

 0000-0001-6421-8429  ORCID identifier (Anastasia J. Hobbach)

 0000-0002-2044-2602  ORCID identifier (Anna Hucke)

 0000-0002-4022-8531  ORCID identifier (Katharina Sielemann)

 0000-0001-5137-7228  ORCID identifier (Katrin Streckfuß-Bömeke)

 0000-0002-5942-361X  ORCID identifier (Gerd Hasenfuß)

 0000-0002-5980-2257  ORCID identifier (Alexander Goedel)

 0000-0001-5782-7832  ORCID identifier (Alessandra Moretti)

 0000-0003-1052-7490  ORCID identifier (Cristobal G. dos Remedios)

 0000-0002-4515-1609  ORCID identifier (Holger Reinecke)

 0000-0001-8871-112X  ORCID identifier (Ralph Knöll)

 0000-0001-9593-1980  ORCID identifier (Sebastiaan van Heesch)

 0000-0002-1218-6223  ORCID identifier (Norbert Hubner)

 0000-0003-1190-4040  ORCID identifier (Wolfram-Hubertus Zimmermann)

 0000-0001-9722-0007  ORCID identifier (Hendrik Milting)

 0000-0003-0801-3773  ORCID identifier (Wolfgang A. Linke)

 363  Published Data Registry entry (MBExC)

 1/345  Research Data Archive MBExC (supplemental material)

 0493xsw21  ROR identifier (0493xsw21, Berlin Institute of Health at Charité - Universitätsmedizin Berlin)

 001w7jn25  ROR identifier (001w7jn25, Charité - University Medicine Berlin)

 031t5w623  ROR identifier (031t5w623, German Centre for Cardiovascular Research)

 04p5ggc03  ROR identifier (04p5ggc03, Max Delbrück Center for Molecular Medicine)

 05xy1nn52  ROR identifier (05xy1nn52, Multiscale Bioimaging)

 021ft0n22  ROR identifier (021ft0n22, Universitätsmedizin Göttingen)

 01856cw59  ROR identifier (01856cw59, University Hospital Münster)

 03zcpvf19  ROR identifier (03zcpvf19, University Hospitals of the Ruhr-University of Bochum)

 01y9bpm73  ROR identifier (01y9bpm73, University of Göttingen)

 SCR_002798  SciCrunch identifier (RRID:SCR_002798, GraphPad Prism)

 SCR_010233  SciCrunch identifier (RRID:SCR_010233, Illumina)

 science....sm.pdf  Supplemental material

 science....s2.zip  Supplemental material

 goeseek.gwdguser.de/studies/124  Supplemental material (goeseek study)

 en.bio-p...bd3079  Supplemental material (protocol on request at bio-protocol.org)

Linked Antibodies

PIDAGTypeAntigen symbolAntibody Registry IDName
umg-sfb1002-antibody-primary-120primaryACTN2AB_476766Monoclonal Anti-α-Actinin (Sarcomeric) antibody produced in mouse
umg-sfb1002-antibody-primary-879primaryAB_628423Ub Antikörper (P4D1)
umg-sfb1002-antibody-primary-1273primaryNANOGAB_2539867Nanog Polyclonal Antibody
umg-sfb1002-antibody-primary-1274primaryAB_354975Goat Anti-Human Oct-3 / 4 Polyclonal antibody, Unconjugated
umg-sfb1002-antibody-primary-1275primaryPOU5F1AB_1645318Alexa Fluor® 647 Mouse anti-Oct3/4
umg-sfb1002-antibody-primary-1278primaryAB_778563Mouse Anti-Human TRA-1-60 Monoclonal Antibody, Unconjugated, Clone TRA-1-60
umg-sfb1002-antibody-primary-1279primaryAB_1645379Alexa Fluor® 488 Mouse anti-Human TRA-1-60 Antigen Clone TRA-1-60 antibody
umg-sfb1002-antibody-primary-1302primaryAB_1523120alpha B Crystallin antibody [EPR2752]
umg-sfb1002-antibody-primary-1308primaryGAPDH AB_561053Rabbit Anti-GAPDH Monoclonal Antibody, Unconjugated, Clone 14C10
umg-sfb1002-antibody-primary-1314primaryAB_2307392Peroxidase AffiniPure Goat Anti-Mouse IgG (H+L)
umg-sfb1002-antibody-primary-1315primaryAB_10262463anti Rabbit IgG (H+L chain) antibody
umg-sfb1002-antibody-primary-1336primaryAB_915950LC3B Antibody
umg-sfb1002-antibody-primary-1337primarySQSTM1AB_2810880Recombinant Anti-SQSTM1 / p62 antibody [EPR4844] - Autophagosome Marker
umg-sfb1002-antibody-primary-1338primaryAB_2734750TTN-9 antibody
umg-sfb1002-antibody-secondary-818secondaryAB_141607Donkey anti-Mouse IgG (H+L) Highly Cross-Adsorbed Secondary Antibody
umg-sfb1002-antibody-secondary-990secondaryAB_162543Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor 555
umg-sfb1002-antibody-secondary-1280secondaryAB_2535853Donkey anti-Goat IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 555
umg-sfb1002-antibody-secondary-1339secondaryAB_955439Goat Anti-Mouse IgG - H&L Polyclonal Antibody, HRP Conjugated
umg-sfb1002-antibody-secondary-1340secondaryAB_955447Goat Anti-Rabbit IgG - H&L Polyclonal antibody, Hrp Conjugated
umg-sfb1002-antibody-secondary-1341secondaryAB_2337381Peroxidase-AffiniPure Goat Anti-Chicken IgY (IgG) (H+L) (min X Bov,Gt,GP,Sy Hms,Hrs,Hu,Ms,Rb,Rat,Shp
umg-sfb1002-antibody-secondary-1342secondaryAB_2338868Alexa Fluor 488-AffiniPure F(ab')2 Fragment Goat Anti-Mouse IgG (H+L) (min X Hu,Bov,Hrs,Rb,Sw Sr Pro
umg-sfb1002-antibody-secondary-1343secondaryAB_2338007Cy3-AffiniPure F(ab')2 Fragment Goat Anti-Rabbit IgG (H+L) antibody